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Identification and molecular characterization of highly divergent RNA viruses in cattle, Uganda

Balinandi, Stephen and Hayer, Juliette and Cholleti, Harindranath and Wille, Michelle and Lutwama, Julius J. and Malmberg, Maja and Mugisha, Lawrence (2022). Identification and molecular characterization of highly divergent RNA viruses in cattle, Uganda. Virus Research. 313 , 198739
[Research article]

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Abstract

The risk for the emergence of novel viral zoonotic diseases in animals and humans in Uganda is high given its geographical location with high biodiversity. We aimed to identify and characterize viruses in 175 blood samples from cattle selected in Uganda using molecular approaches. We identified 8 viral species belonging to 4 families (Flaviviridae, Peribunyaviridae, Reoviridae and Rhabdoviridae) and 6 genera (Hepacivirus, Pestivirus, Orthobunya-virus, Coltivirus, Dinovernavirus and Ephemerovirus). Four viruses were highly divergent and tetantively named Zikole virus (Family: Flaviviridae), Zeboroti virus (Family: Reoviridae), Zebtine virus (Family: Rhabdoviridae) and Kokolu virus (Family: Rhabdoviridae). In addition, Bovine Hepacivirus, Obodhiang virus, Aedes pseudoscutellaris reovirus and Schmallenberg virus were identified for the first time in Ugandan cattle. We report 8 viral species belonging to 4 viral families including divergent ones in the blood of cattle in Uganda. Hence, cattle may be reservoir hosts for likely emergence of novel viruses with pathogenic potential to cause zoonotic diseases in different species with serious public health implications.

Authors/Creators:Balinandi, Stephen and Hayer, Juliette and Cholleti, Harindranath and Wille, Michelle and Lutwama, Julius J. and Malmberg, Maja and Mugisha, Lawrence
Title:Identification and molecular characterization of highly divergent RNA viruses in cattle, Uganda
Series Name/Journal:Virus Research
Year of publishing :2022
Volume:313
Article number:198739
Number of Pages:11
Publisher:ELSEVIER
ISSN:0168-1702
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area
Keywords:Cattle, Zoonoses, pan-PCR, Metagenomics, RNA virus, Uganda
URN:NBN:urn:nbn:se:slu:epsilon-p-117049
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-117049
Additional ID:
Type of IDID
DOI10.1016/j.virusres.2022.198739
Web of Science (WoS)000788426300003
ID Code:27800
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:12 May 2022 16:28
Metadata Last Modified:12 May 2022 16:31

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