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A genome-wide test for paternal indirect genetic effects on lifespan in Drosophila melanogaster

Shenoi, Vinesh Naresh and Brengdahl, Martin and Grace, Jaime L. and Eriksson, Björn and Ryden, Patrik and Friberg, Urban (2022). A genome-wide test for paternal indirect genetic effects on lifespan in Drosophila melanogaster. Proceedings of the Royal Society B: Biological Sciences. 289 :1974 , 20212707
[Research article]

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Abstract

Exposing sires to various environmental manipulations has demonstrated that paternal effects can be non-trivial also in species where male investment in offspring is almost exclusively limited to sperm. Whether paternal effects also have a genetic component (i.e. paternal indirect genetic effects (PIGEs)) in such species is however largely unknown, primarily because of methodological difficulties separating indirect from direct effects of genes. PIGEs may nevertheless be important since they have the capacity to contribute to evolutionary change. Here we use Drosophila genetics to construct a breeding design that allows testing nearly complete haploid genomes (more than 99%) for PIGEs. Using this technique, we estimate the variance in male lifespan due to PIGEs among four populations and compare this to the total paternal genetic variance (the sum of paternal indirect and direct genetic effects). Our results indicate that a substantial part of the total paternal genetic variance results from PIGEs. A screen of 38 haploid genomes, randomly sampled from a single population, suggests that PIGEs also influence variation in lifespan within populations. Collectively, our results demonstrate that PIGEs may constitute an underappreciated source of phenotypic variation.

Authors/Creators:Shenoi, Vinesh Naresh and Brengdahl, Martin and Grace, Jaime L. and Eriksson, Björn and Ryden, Patrik and Friberg, Urban
Title:A genome-wide test for paternal indirect genetic effects on lifespan in Drosophila melanogaster
Series Name/Journal:Proceedings of the Royal Society B: Biological Sciences
Year of publishing :2022
Volume:289
Number:1974
Article number:20212707
Number of Pages:8
Publisher:ROYAL SOC
ISSN:0962-8452
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology
Keywords:Drosophila, paternal indirect genetic effects, lifespan
URN:NBN:urn:nbn:se:slu:epsilon-p-117341
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-117341
Additional ID:
Type of IDID
DOI10.1098/rspb.2021.2707
Web of Science (WoS)000796005500013
ID Code:28242
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Plant Protection Biology
Deposited By: SLUpub Connector
Deposited On:03 Jun 2022 14:25
Metadata Last Modified:03 Jun 2022 14:31

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