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Haplotype analysis of the mitochondrial DNA d-loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo

Simon, Patrick Baenyi and Junga, Joseph Owino and Tarekegn, Getinet Mekuriaw and Machuka, Eunice and Tiambo, Christian Keambou and Kabange, Dorine and Musale, Katunga and Kizungu, Roger Vumilia and Ochieng, Joel Winyo and Pelle, Roger (2022). Haplotype analysis of the mitochondrial DNA d-loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo. Ecology and Evolution. 12 :3 , e8713
[Research article]

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Abstract

This study aimed at assessing haplotype diversity and population dynamics of three Congolese indigenous goat populations that included Kasai goat (KG), small goat (SG), and dwarf goat (DG) of the Democratic Republic of Congo (DRC). The 1169 bp d-loop region of mitochondrial DNA (mtDNA) was sequenced for 339 Congolese indigenous goats. The total length of sequences was used to generate the haplotypes and evaluate their diversities, whereas the hypervariable region (HVI, 453 bp) was analyzed to define the maternal variation and the demographic dynamic. A total of 568 segregating sites that generated 192 haplotypes were observed from the entire d-loop region (1169 bp d-loop). Phylogenetic analyses using reference haplotypes from the six globally defined goat mtDNA haplogroups showed that all the three Congolese indigenous goat populations studied clustered into the dominant haplogroup A, as revealed by the neighbor-joining (NJ) tree and median-joining (MJ) network. Nine haplotypes were shared between the studied goats and goat populations from Pakistan (1 haplotype), Kenya, Ethiopia and Algeria (1 haplotype), Zimbabwe (1 haplotype), Cameroon (3 haplotypes), and Mozambique (3 haplotypes). The population pairwise analysis (F-ST) indicated a weak differentiation between the Congolese indigenous goat populations. Negative and significant (p-value <.05) values for Fu's Fs (-20.418) and Tajima's (-2.189) tests showed the expansion in the history of the three Congolese indigenous goat populations. These results suggest a weak differentiation and a single maternal origin for the studied goats. This information will contribute to the improvement of the management strategies and long-term conservation of indigenous goats in DRC.

Authors/Creators:Simon, Patrick Baenyi and Junga, Joseph Owino and Tarekegn, Getinet Mekuriaw and Machuka, Eunice and Tiambo, Christian Keambou and Kabange, Dorine and Musale, Katunga and Kizungu, Roger Vumilia and Ochieng, Joel Winyo and Pelle, Roger
Title:Haplotype analysis of the mitochondrial DNA d-loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo
Series Name/Journal:Ecology and Evolution
Year of publishing :2022
Volume:12
Number:3
Article number:e8713
Number of Pages:10
Publisher:WILEY
ISSN:2045-7758
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
Keywords:Democratic Republic of Congo, genetic diversity, haplogroup, mismatch distribution pattern, population expansion
URN:NBN:urn:nbn:se:slu:epsilon-p-116792
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-116792
Additional ID:
Type of IDID
DOI10.1002/ece3.8713
Web of Science (WoS)000774768200001
ID Code:28267
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:08 Jun 2022 11:25
Metadata Last Modified:08 Jun 2022 11:31

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