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Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables

Wesselowski, S. and Gordon, S. G. and Meddaugh, N. and Saunders, A. B. and Häggström, Jens and Cusack, K. and Janacek, B. W. and Matthews, D. J. (2022). Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables. Journal of Veterinary Cardiology. 40 , 126-141
[Research article]

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Abstract

Introduction: Large breed (LB) dogs develop dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD). Echocardiography is required for a definitive diagnosis but is not always available. Our objective was to assess the clinical utility of thoracic radiographs alone and in combination with physical examination and electrocardiography findings for the prediction of clinically important DCM or MMVD in LB dogs. Animals: Four hundred fifty-five client-owned dogs >20 kg with concurrent thoracic radiographs and echocardiogram. Materials and methods: Medical records were reviewed and stored thoracic radio-graphs and echocardiographic images were measured to classify dogs as normal heart size (NHS), preclinical DCM, clinical DCM, preclinical MMVD (with cardiome-galy), clinical MMVD, or equivocal. Dogs with preclinical MMVD, without cardiome-galy, were classified as NHS. Vertebral heart size (VHS) and vertebral left atrial size (VLAS) were measured. Receiver operating characteristic curves and prediction models were derived. Results: Prevalence of MMVD (39 .3%) was higher than the prevalence of DCM (24.8%), though most MMVD dogs (67.0%) lacked cardiomegaly and were classified as NHS for analysis. The area under the curve for VHS to discriminate between NHS and clinical DCM/MMVD or preclinical DCM/MMVD was 0.861 and 0.712, respec-tively, while for VLAS, it was 0.891 and 0.722, respectively. Predictive models incor-porating physical examination and electrocardiography findings in addition to VHS/ VLAS increased area under the curve to 0.978 (NHS vs. clinical DCM/MMVD) and 0.829 (NHS vs. preclinical DCM/MMVD). Conclusions: Thoracic radiographs were useful for predicting clinically important DCM or MMVD in LB dogs, with improved discriminatory ability when physical exam-ination abnormalities and arrhythmias were accounted for.@ 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Authors/Creators:Wesselowski, S. and Gordon, S. G. and Meddaugh, N. and Saunders, A. B. and Häggström, Jens and Cusack, K. and Janacek, B. W. and Matthews, D. J.
Title:Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables
Series Name/Journal:Journal of Veterinary Cardiology
Year of publishing :2022
Volume:40
Page range:126-141
Number of Pages:16
Publisher:ELSEVIER
ISSN:1760-2734
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Dilated cardiomyopa-thy, Myxomatous mitral valve disease, VHS, VLAS, Murmur
URN:NBN:urn:nbn:se:slu:epsilon-p-117358
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-117358
Additional ID:
Type of IDID
DOI10.1016/j.jvc.2021.07.003
Web of Science (WoS)000797855000010
ID Code:28289
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:09 Jun 2022 12:27
Metadata Last Modified:09 Jun 2022 12:31

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