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Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation

Sturm, Sabina and Weber, Klaus and Klinc, Primoz and Spörndly-Nees, Ellinor and Fakhrzadeh, Azadeh and Knific, Tanja and Skibin, Andrej and Fialova, Vera and Okazaki, Yoshimasa and Razinger, Tanja and Laufs, Jurgen and Kreutzer, Robert and Pogacnik, Milan and Svara, Tanja and Cerkvenik-Flajs, Vesna (2022). Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation. Toxics. 10 :5 , 224
[Research article]

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Abstract

Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 mu g/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected.

Authors/Creators:Sturm, Sabina and Weber, Klaus and Klinc, Primoz and Spörndly-Nees, Ellinor and Fakhrzadeh, Azadeh and Knific, Tanja and Skibin, Andrej and Fialova, Vera and Okazaki, Yoshimasa and Razinger, Tanja and Laufs, Jurgen and Kreutzer, Robert and Pogacnik, Milan and Svara, Tanja and Cerkvenik-Flajs, Vesna
Title:Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation
Series Name/Journal:Toxics
Year of publishing :2022
Volume:10
Number:5
Article number:224
Number of Pages:17
Publisher:MDPI
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
Keywords:bisphenol A, rams, toxicokinetics, male toxicity, sperm
URN:NBN:urn:nbn:se:slu:epsilon-p-117578
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-117578
Additional ID:
Type of IDID
DOI10.3390/toxics10050224
Web of Science (WoS)000804902800001
ID Code:28596
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:26 Aug 2022 11:21
Metadata Last Modified:26 Aug 2022 11:31

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