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Factors influencing stoichiometry and stability of polyoxometalate - peptide complexes

Greijer, Björn and Nestor, Gustav and Eriksson, Jan and Seisenbaeva, Gulaim and Kessler, Vadim (2022). Factors influencing stoichiometry and stability of polyoxometalate - peptide complexes. Dalton Transactions. 51 :24 , 9511-9521
[Research article]

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Abstract

In the pursuit of understanding the factors guiding interactions between polyoxometalates (POMs) and biomolecules, several complexes between Keggin phosphomolybdate and diglycine have been produced at different acidity and salinity conditions, leading to difference in stoichiometry and in crystal structure. Principal factors determining how the POM and dipeptide interact appear to be pH, ionic strength of the medium, and the molar ratio of POM to peptide. An important effect turned out to be even the structure-directing role of the sodium cations coordinating carbonyl functions of the peptide bond. Given the interest in applying POMs in biological systems, these factors are highly relevant to consider. In the view of recent interest in using POMs as nano catalysts in peptide hydrolysis also the potential Keggin POM transformation in phosphate buffered saline medium was investigated leading to insight that nanoparticles of zirconium phosphate (ZrP) can be actual catalysts for breakdown of the peptide bond.

Authors/Creators:Greijer, Björn and Nestor, Gustav and Eriksson, Jan and Seisenbaeva, Gulaim and Kessler, Vadim
Title:Factors influencing stoichiometry and stability of polyoxometalate - peptide complexes
Series Name/Journal:Dalton Transactions
Year of publishing :2022
Volume:51
Number:24
Page range:9511-9521
Number of Pages:11
Publisher:ROYAL SOC CHEMISTRY
ISSN:1477-9226
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 3.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Inorganic Chemistry
URN:NBN:urn:nbn:se:slu:epsilon-p-118030
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-118030
Additional ID:
Type of IDID
DOI10.1039/d2dt00717g
Web of Science (WoS)000810088000001
ID Code:28667
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:30 Aug 2022 14:10
Metadata Last Modified:12 Sep 2022 17:30

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