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Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees

Ribeiro, Henrique G. and Nilsson, Anna and Melo, Luis D. R. and Oliveira, Ana (2022). Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees. Frontiers in Microbiology. 13 , 903861
[Research article]

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Abstract

Paenibacillus larvae is the etiological agent of American Foulbrood (AFB), a highly contagious and worldwide spread bacterial disease that affects honeybee brood. In this study, all complete P. larvae genomes available on the NCBI database were analyzed in order to detect presence of prophages using the PHASTER software. A total of 55 intact prophages were identified in 11 P. larvae genomes (5.0 +/- 2.3 per genome) and were further investigated for the presence of genes encoding relevant traits related to P. larvae. A closer look at the prophage genomes revealed the presence of several putative genes such as metabolic and antimicrobial resistance genes, toxins or bacteriocins, potentially influencing host performance. Some of the coding DNA sequences (CDS) were present in all ERIC-genotypes, while others were only found in a specific genotype. While CDS encoding toxins and antitoxins such as HicB and MazE were found in prophages of all bacterial genotypes, others, from the same category, were provided by prophages particularly to ERIC I (enhancin-like toxin), ERIC II (antitoxin SocA) and ERIC V strains (subunit of Panton-Valentine leukocidin system (PVL) LukF-PV). This is the first in-depth analysis of P. larvae prophages. It provides better knowledge on their impact in the evolution of virulence and fitness of P. larvae, by discovering new features assigned by the viruses.

Authors/Creators:Ribeiro, Henrique G. and Nilsson, Anna and Melo, Luis D. R. and Oliveira, Ana
Title:Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
Series Name/Journal:Frontiers in Microbiology
Year of publishing :2022
Volume:13
Article number:903861
Number of Pages:18
Publisher:FRONTIERS MEDIA SA
ISSN:1664-302X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109)
Keywords:Paenibacillus larvae, prophage, bacterial evolution, bacterial fitness, bacterial virulence
URN:NBN:urn:nbn:se:slu:epsilon-p-118589
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-118589
Additional ID:
Type of IDID
DOI10.3389/fmicb.2022.903861
Web of Science (WoS)000834612000001
ID Code:28688
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Ecology
(S) > Dept. of Ecology
Deposited By: SLUpub Connector
Deposited On:31 Aug 2022 13:27
Metadata Last Modified:31 Aug 2022 13:31

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