Home About Browse Search
Svenska


Impact of synthetic surfactant CHF5633 with SP-B and SP-C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome

Mikolka, Pavol and Curstedt, Tore and Feinstein, Riccardo and Larsson, Anders and Grendar, Marian and Rising, Anna and Johansson, Jan (2021). Impact of synthetic surfactant CHF5633 with SP-B and SP-C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome. Physiological Reports. 9 :1 , e14700
[Research article]

Full text not available from this repository.

Abstract

Acute respiratory distress syndrome (ARDS) is associated with diffuse inflammation, alveolar epithelial damage, and leakage of plasma proteins into the alveolar space, which together contribute to inactivation of pulmonary surfactant and respiratory failure. Exogenous surfactant delivery is therefore considered to hold potential for ARDS treatment, but clinical trials with natural derived surfactant or synthetic surfactant containing a surfactant protein C (SP-C) analogue have been negative. Synthetic surfactant CHF5633, containing analogues of SP-B and SP-C, may be effective against ARDS. The aim here was to compare treatment effects of CHF5633 and animal-derived surfactant poractant alfa in animal model of ARDS. ARDS was induced in adult New Zealand rabbits by mild lung lavages followed by injurious ventilation until respiratory failure (P/F ratio

Authors/Creators:Mikolka, Pavol and Curstedt, Tore and Feinstein, Riccardo and Larsson, Anders and Grendar, Marian and Rising, Anna and Johansson, Jan
Title:Impact of synthetic surfactant CHF5633 with SP-B and SP-C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome
Series Name/Journal:Physiological Reports
Year of publishing :2021
Volume:9
Number:1
Article number:e14700
Number of Pages:12
Publisher:WILEY
ISSN:2051-817X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:None
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Physiology
Keywords:ARDS model, CHF5633, inflammation, lung function, synthetic pulmonary surfactant
URN:NBN:urn:nbn:se:slu:epsilon-p-118681
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-118681
Additional ID:
Type of IDID
DOI10.14814/phy2.14700
Web of Science (WoS)000609502400004
ID Code:28770
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:05 Sep 2022 08:25
Metadata Last Modified:05 Sep 2022 08:31

Repository Staff Only: item control page