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Enteric diseases in pigs from weaning to slaughter

Jacobson, Magdalena (2003). Enteric diseases in pigs from weaning to slaughter. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae. Veterinaria, 1401-6257 ; 158
ISBN 91-576-6387-4
[Doctoral thesis]

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Abstract

The general aim of this thesis was to study enteric diseases in growing pigs, with special reference to diseases caused by Brachyspira hyodysenteriae and Lawsonia intracellularis. The occurrence of enteric diseases in “growers” is a problem of increasing importance in Sweden and an understanding of the mechanisms by which the microorganisms causes enteric diseases is essential to develop good prophylactic measures. The most important microorganisms involved in enteric diseases in grower pigs were identified as Lawsonia intracellularis and Brachyspira pilosicoli, as determined by necropsy, microbiological and histopathological examinations performed on representative growing pigs from good and poor performing herds. Diagnostic methods based on polymerase chain reaction for L. intracellularis in tissue or faecal samples were established and the results related to those obtained by necropsy and serology. An internal control, a mimic, was constructed to demonstrate inhibition of the PCR reactions and to evaluate different preparation methods. The methods for the demonstration of L. intracellularis in tissue samples were sensitive and specific, and the bacteria were reliably identified in faeces from pigs with overt disease. A number of factors interacting in the clinical expression of swine dysentery were evaluated. In this work, group-housing of pigs and the addition of 50% soybean meal in feed was shown to predispose for infection. A model was developed that enabled the sequential monitoring of disease in single animals by repeated endoscopy and biopsy sampling through a caecal cannula. This reduced the number of experimental animals required and increased the accuracy of the study. The general condition of the animal was not affected. The model was used to study the development of experimentally induced swine dysentery and the sequential development of lesions was characterised by histopathology and immunohistochemistry. An increase in the acute phase proteins serum amyloid A and haptoglobin and in monocytes was seen when haemorrhagic dysentery occurred.

Authors/Creators:Jacobson, Magdalena
Title:Enteric diseases in pigs from weaning to slaughter
Year of publishing :September 2003
Volume:158
Number of Pages:51
Papers/manuscripts:
NumberReferences
ALLI. Jacobson, M., Hård af Segerstad, C., Gunnarsson, A., Fellström, C., de Verdier Klingenberg, K., Wallgren, P. & Jensen-Waern, M. 2003. Diarrhoea in the growing pig – a comparison of clinical, morphological and microbial findings between animals from good and poor performance herds. Research in Veterinary Science, 74:163-169 II. Jacobson, M., Englund, S. & Ballagi-Pordány, A. 2003. The use of a mimic to detect polymerase chain reaction inhibitory factors in feces examined for the presence of Lawsonia intracellularis. Journal of Veterinary Diagnostic Investigation, 15:268-273 III. Jacobson, M., Aspan, A., Heldtander Königsson, M., Hård af Segerstad, C., Wallgren P., Fellström, C., Jensen Waern, M. & Gunnarsson, A. Diagnosis of Lawsonia intracellularis performed by PCR, serological and post mortem examination, with special emphasis on sample preparation methods for PCR. Submitted for publication. IV. Jacobson, M., Lindberg, J. E., Lindberg, R., Hård af Segerstad, C., Wallgren, P., Fellström, C., Hultén, C. & Jensen-Waern, M. 2001. Intestinal cannulation: Model for study of the midgut of the pig. Comparative Medicine, 51:163-170 V. Jacobson, M., Fellström, C., Lindberg, R., Wallgren, P. & Jensen-Waern, M. Experimental swine dysentery – comparison between infection models and studies of the acute phase protein response to infection. Submitted for publication. VI. Jacobson, M., Lindberg, R., Jonasson, R., Fellström, C. & Jensen-Waern, M. Consecutive pathological and immunological alterations during experimentally induced swine dysentery – a study performed by repeated endoscopy and biopsy samplings through an intestinal cannula. In manuscript.
Place of Publication:Uppsala
ISBN for printed version:91-576-6387-4
ISSN:1401-6257
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:Not in use, please see Agris categories
Agrovoc terms:swine, enteritis, animal models, experimentation, immune response, leukocytes, lymphocytes, diarrhoea
Keywords:Experimental animal model, cortisol, enteric pathogens, immune response, white blood cells, T lymphocytes, mucohaemorrhagic diarrhoea
URN:NBN:urn:nbn:se:slu:epsilon-74
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-74
ID Code:353
Department:(VH) > Institutionen för kirurgi och medicin, Stordjur (970101-040630)
Deposited By: Staff Epsilon
Deposited On:17 Sep 2003 00:00
Metadata Last Modified:02 Dec 2014 10:04

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