Home About Browse Search
Svenska


Diagnostic imaging of cardiopulmonary structures in normal dogs and dogs with mitral regurgitation

Hansson, Kerstin (2004). Diagnostic imaging of cardiopulmonary structures in normal dogs and dogs with mitral regurgitation. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae. Veterinaria, 1401-6257 ; 167
ISBN 91-576-6654-7
[Doctoral thesis]

[img]
Preview
PDF
159kB

Abstract

The general aim of this thesis was to evaluate two different imaging techniques used to evaluate the heart of dogs with mitral regurgitation, one for measurements of left atrial size and one for general cardiac size and to compare cardiopulmonary imaging with plasma levels of natriuretic peptides. A more specific aim was to study the variability in objective measurements of left atrial and cardiac size and subjective evaluation of general cardiomegaly, left atrial enlargement and radiologic signs of congestive heart failure among groups of observers with varying experience in thoracic radiology. The experience levels included were; experienced radiologists, experienced small animal clinicians, trainees for a small animal specialist degree and veterinary students. General heart enlargement can be monitored by objective measurements but there is no way to objectively estimate left atrial size on radiographs. An established index method for measurements of left atrial size on M-mode echocardiogram was compared to an index that uses the two-dimensional (2-D) image for dimensional measurements. It was shown that the 2-D index can be used as a good predictor of left atrial size. The 2-D index had a greater sensitivity for left atrial enlargement compared to the M-mode index. Plasma levels of natriuretic peptides (ANP, NT-proANP and BNP) were studied as endogenous markers for increase in left atrial and ventricular size and left ventricular dysfunction. The plasma levels of the studied peptides did not increase in any significant way until there was radiologic and echocardiographic evidence of cardiac enlargement. However, the peptides were shown to be efficient in separating compensated from decompensated heart failure. In the objective measurement of heart size the interobserver variation of the vertebral heart size method had a mean variation among the 16 observers of around 1.0 VHS units. No difference in mean VHS values was found among the four groups of observers. The subjective evaluation had a large discrepancy amongst both the observers and between the observers and the gold standard. In general the observers overdiagnosed signs of congestive heart failure and underdiagnosed left atrial and general heart enlargement. Accuracy in the subjective interpretation of general cardiomegaly, left atrial enlargement and radiologic signs of congestive heart failure was not in any conclusive way affected by observer experience. Objective measurements of cardiac size were independent of observer experience but dependent on individual observers´ selection of reference points for measurements.

Authors/Creators:Hansson, Kerstin
Title:Diagnostic imaging of cardiopulmonary structures in normal dogs and dogs with mitral regurgitation
Year of publishing :January 2004
Volume:167
Number of Pages:45
Papers/manuscripts:
NumberReferences
ALLI. Hansson K., Häggström J., Kvart C. & Lord P. 2002. Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in cavalier King Charles spaniels with and without left atrial enlargement. Veterinary Radiology & Ultrasound 43, 568-575. II. Häggström J., Hansson K., Kvart C., Duelund Pedersen H., Vuolteenaho O. & Olsson K. 2000. Relationship between different natriuretic peptides and severity of naturally acquired mitral regurgitation in dogs with chronic myxomatous valve disease. Journal of Veterinary Cardiology 2, 7-16. III. Hansson K., Häggström J., Kvart C. & Lord P. 2003. Variability among observers of vertebral heart size measurements in dogs with normal and enlarged hearts. Submitted for publication. IV. Hansson K., Häggström J., Kvart C. & Lord P. 2004. Variability among observers evaluating heart enlargement and pulmonary edema on thoracic radiographs in normal dogs and dogs with mitral regurgitation. Manuscript.
Place of Publication:Uppsala
ISBN for printed version:91-576-6654-7
ISSN:1401-6257
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:Not in use, please see Agris categories
Agrovoc terms:dogs, heart, heart diseases, image analysis, technology, methods, diagnosis
Keywords:Left atrial size, LA/AO index, atrial natriuretic peptide, NT-proANP, BNP, VHS, interobserver variation, ROC, subjective interpretation, observer experience
URN:NBN:urn:nbn:se:slu:epsilon-121
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-121
ID Code:449
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: Kerstin Hansson
Deposited On:19 Jan 2004 00:00
Metadata Last Modified:02 Dec 2014 10:05

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits