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Ancient roles of non-coding RNAs in eukaryotic evolution

contributions from social amoebae and other protists

Avesson, Lotta (2011). Ancient roles of non-coding RNAs in eukaryotic evolution. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2011:70
ISBN 978-91-576-7614-6
[Doctoral thesis]

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Abstract

RNAs not coding for proteins, non-coding RNAs (ncRNAs) have many important roles in all kingdoms of life. Especially in eukaryotes, the regulatory functions of ncRNAs have been suggested as a major force in the evolution of complex traits. Cellular processes that are regulated by ncRNAs include for example cell differentiation, organ development and defense against viruses and transposable elements. This is achieved through a number of mechanisms like RNA destabilization and modification, transcriptional and translational control and chromatin modifications.

Dictyostelium discoideum is a social amoeba and the best studied organism representing Amoebozoa, one of the eukaryotic supergroups. It has for long served as an excellent model for many basic cellular events like chemotaxis, differentiation and development and recently also for infection. The ncRNA population in D. discoideum is in many ways typical of eukaryotes but also harbors particularities. In this thesis I have studied spliceosomal RNAs as well as the RNA interference and microRNA pathways, which probably were present in the last eukaryotic common ancestor. I have also characterized Class I RNAs which seems to be specific to social amoebae. In addition, we have described the signal recognition particle RNA in several protists and also the involvement of a ncRNA during host interaction and stress in Giardia lamblia.

Combining the well established molecular tools and knowledge about various pathways in D. discoideum, with the growing understanding of ncRNA, could in the future give important information about the function of ncRNAs as well as their ancient roles and evolution.

Authors/Creators:Avesson, Lotta
Title:Ancient roles of non-coding RNAs in eukaryotic evolution
Subtitle:contributions from social amoebae and other protists
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2011
Volume:2011:70
Number of Pages:76
Papers/manuscripts:
NumberReferences
I.*Hinas, A., *Larsson, P., Avesson, L., Kirsebom, L. A., Virtanen, A., and Söderbom, F. (2006) Identification of the major spliceosomal RNAs in Dictyostelium discoideum reveals developmentally regulated U2 variants and polyadenylated snRNAs. Eukaryotic Cell 5(6), 924-34.
II.Ringqvist, E., Avesson, L., Söderbom F., and Svärd, S.G. (2011) Transcriptional changes in Giardia during host-parasite interactions. Int. J. Parasitol. 41(3-4), 277-85.
III.Avesson, L., Schumacher, H.T., Romby, P., Fechter, P., Hellman, U., Söderbom, F. (2011) An abundant class of non-coding RNA regulates development in the social amoeba Dictyostelium discoideum. RNA Biology 8(6), In press
IV.Avesson, L., Reimegård, J., Wagner, E.G.H., and Söderbom, F. Abundantly expressed class of non-coding RNA conserved throughout evolution of Dictyostelia. Manuscript
V.*Avesson, L., *Reimegård, J., Wagner, E.G.H., and Söderbom, F. The small RNA population in D. discoideum during growth and development. Manuscript
UNSPECIFIED* These authors contributed equally
Place of Publication:Uppsala
Publisher:Dept. of Molecular Biology, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-7614-6
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:X Agricola extesions > X30 Life sciences
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
Agrovoc terms:rna, dictyostelium discoideum, evolution, giardia duodenalis
Keywords:non-coding RNA, Dictyostelium discoideum, evolution, microRNA
URN:NBN:urn:nbn:se:slu:epsilon-e-190
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-190
ID Code:8295
Department:(NL, NJ) > Dept. of Molecular Biology (until 131231)
Deposited By: Lotta Avesson
Deposited On:29 Aug 2011 12:42
Metadata Last Modified:02 Dec 2014 10:47

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