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Swine influenza A virus subtype H1N2 in Sweden

Metreveli, Giorgi (2012). Swine influenza A virus subtype H1N2 in Sweden. Uppsala : Sveriges lantbruksuniv. , Report (Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences), 1653-8315 ; 6
ISBN 978-91-576-9079-1
[Licentiate thesis]

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The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species when new human influenza pandemics arise. All previous pandemics have been suggested to evolve in pigs from viral genes of avian, human and porcine origin. Therefore, it is of major importance to monitor the evolution of swine influenza viruses in pigs, and in particular monitor hallmarks of species adaptation to humans.The scope of this project was to increase the understanding of the genetics of swine influenza virus (SIV), with special emphasis on its zoonotic potential, and to investigate the importance of different viral gene markers for species specificity and adaptation. Since clinical manifestation of swine influenza is rare in Sweden, and SIV strains are of particular concern due to the novel human H1N1 epidemic, viruses were isolated in primary swine kidney or Madin Darby Canine Kidney (MDCK) cells, based on standard protocols and the isolates were subjected to full genome sequencing and
comparative sequence analysis of the viral genomes. The results describe the analysis of the whole genome sequences from two swine influenza viruses isolated from Sweden in 2009 and 2010. Moreover, this study demonstrates, for the first time, natural reassortment in H1N2 viruses in the pig populations of Sweden. Biological characterization of the two viruses revealed a weaker growing potential, compared to the Swedish 2002 H1N1 isolate. Sequence comparison revealed significant differences between the two consecutive H1N2 isolates. The most remarkable of these was a truncated coding region for PB1-F2 in the earlier isolates and a full length coding region in the more recent isolates. In order to determine the effect of these viruses on the swine industry and on influenza ecology, further surveillance investigations and detailed analyses are needed.

Authors/Creators:Metreveli, Giorgi
Title:Swine influenza A virus subtype H1N2 in Sweden
Series Name/Journal:Report (Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences)
Year of publishing :2012
Number of Pages:44
IBálint A, Metreveli G, Widén F, Zohari S, Berg M, Isaksson M, Renström LH, Wallgren P, Belák S, Segall T, Kiss I. (2009) The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. Virology Journal 6:180
IIMetreveli G, Emmoth E, Zohari S, Bálint Á, Widén F, Muradrasoli S, Wallgren P, Belák S, LeBlanc N, Berg M, Kiss I. (2011) Comparison of two H1N2 swine influenza A viruses from disease outbreaks in pigs in Sweden during 2009 and 2010. Virus Genes 42, 236-244.
Place of Publication:Uppsala
Publisher:Institutionen för biomedicin och veterinär folkhälsovetenskap, Sveriges lantbruksuniversitet
ISBN for printed version:978-91-576-9079-1
Publication Type:Licentiate thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L10 Animal genetics and breeding
L Animal production > L73 Animal diseases
Subjects:Obsolete subject words > VETERINARY MEDICINE > Microbiology and immunology
Obsolete subject words > VETERINARY MEDICINE > Other veterinary medicine
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
Agrovoc terms:swine influenzavirus, swine, zoonoses, epidemiology, sweden
Keywords:influenza A, swine influenza virus SIV, comparison
Permanent URL:
ID Code:8891
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: Giorgi Metreveli
Deposited On:16 May 2012 11:09
Metadata Last Modified:13 May 2015 10:18

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