eprintid: 8589
rev_number: 51
eprint_status: archive
userid: 6888
dir: disk0/00/00/85/89
datestamp: 2012-02-10 11:10:01
lastmod: 2014-12-02 10:48:52
status_changed: 2012-02-10 11:10:01
type: diss
metadata_visibility: show
contact_email: Odd.Hoglund@slu.se
creators_name: Höglund, Odd Viking
creators_id: Odd.Hoglund@slu.se
creators_yearofbirth: 1969
title: A resorbable device for ligation of blood vessels
ispublished: pub
subjects: SCB1662
subjects: SCB22
subjects: SSIF-30212
subjects: VR183204
subjects: VR183207
faculties: SLU.id.orga.faculty-VH
divisions: 7042
full_text_status: public
abstract: Maintaining haemostasis during surgery is vital for a successful outcome. The objectives of this thesis were to develop a resorbable device, which would enable safe ligation and less surgical stress than the conventional method. For manufacturing of the device, the resorbable polymer polydioxanone was injection moulded. The device was constructed as a flexible band attached to a self-locking mechanism. The band formed a loop around the tissue, the end of the band was inserted into the locking mechanism and was pulled through until the loop was closed. The design allowed complete closure of the loop and the device resisted ligature slip-off from renal arteries at 10 N. Tissue reactions and surgical stress responses to ligation with the device were studied in healthy dogs subjective to elective neutering. For evaluation of haemostatic efficiency the ovarian pedicles of 14 dogs were ligated bilaterally (9) or unilaterally (5). All pedicles were successfully ligated, but one device first after being further tightened. The dogs were examined by ultrasound for up to twelve months with no adverse observations recorded. In two dogs histological examinations revealed local and transient tissue reactions around the devices. Systolic blood pressure and heart rate were registered during ligation of ovarian pedicles bilaterally in nine dogs and unilaterally in five dogs using the device and in 26 dogs using conventional techniques. In 16 of the 26 dogs laparoscopic and open abdomen techniques were compared and in the remaining 10 dogs ligation of the two ovaries was compared. Plasma vasopressin was analysed in the latter study. The increase in systolic blood pressure was greater in the open abdomen group compared to the laparoscopic group and the device-group. Ligation of the first ovarian pedicle caused a greater cardiovascular response than ligation of the second pedicle. However, plasma vasopressin concentration changed in synchrony with systolic blood pressure and the combination may be useful for evaluation of surgical stress. In conclusion, a resorbable device which efficiently ligated both single vessels and ovarian pedicles was successfully constructed. Whether use of the device enables less surgical stress than a conventional ligation technique remains to be clarified.
date: 2012
series: Acta Universitatis agriculturae Sueciae
volume: 2012:2
place_of_pub: Uppsala
pages: 73
department: Dept. of Clinical Sciences
isbn: 978-91-576-7686-3
issn: 1652-6880
acceptagreement: TRUE
agrovoc: dogs
agrovoc: injection
agrovoc: blood vessels
agrovoc: surgical operations
agrovoc: stress
agrovoc: methods
diss_articles_id: I.
diss_articles_id: II.
diss_articles_id: III.
diss_articles_id: IV.
diss_articles_reference: Odd V. Höglund, Ragnvi Hagman, Kerstin Olsson, Jonas Mindemark, Niklas Borg and Anne-Sofie Lagerstedt (2011). A new resorbable device for ligation of blood vessels - A pilot study. Acta Veterinaria Scandinavica 53(47), 1-7.
diss_articles_reference: Odd V. Höglund, Ragnvi Hagman, Kerstin Olsson, Carolina Carlsson, Fredrik Södersten, Anne-Sofie Lagerstedt (2011). Ligation of the ovarian pedicles in dogs with a resorbable self-locking device – A long-term follow-up study. Journal of Biomaterials Applications, e-pub before print.
diss_articles_reference: Odd V. Höglund, Kerstin Olsson, Ragnvi Hagman, Malin Öhlund, Ulf Olsson, Anne-Sofie Lagerstedt (2011). Comparison of haemodynamic changes during two surgical methods for neutering female dogs. Research in Veterinary Science 91, 159-163.
diss_articles_reference: Odd V. Höglund, Ragnvi Hagman, Kerstin Olsson, Ulf Olsson, Anne-Sofie Lagerstedt. Intraoperative changes of blood pressure, heart rate, plasma vasopressin and urinary noradrenalin during elective ovariohysterectomy in dogs. Manuscript. 
Papers I-III are reproduced with the permission of the publishers.
urn_nbn: urn:nbn:se:slu:epsilon-e-349
oa_institution: slu
oa_keywords: dog
oa_keywords: injection moulding
oa_keywords: surgical stress
language: eng
libris: TRUE
noofarticles: 4
pbas: TRUE
oa_publisher: Department of Clinical Sciences, Swedish University of Agricultural Sciences
oa_series: Acta Universitatis agriculturae Sueciae (1652-6880)
faculty: VH
titlesub: development, assessment of surgical procedures and clinical evaluation
diss_subjects: L70
stakeholders: SLU.id.future.prog-animalhealth
oa_store_key: AgrisRN
oa_store_value: SE2012008589
slu_log_base: 1703
slu_log_count: 4171
citation:   Höglund, Odd Viking  (2012). A resorbable device for ligation of blood vessels.  Diss. (sammanfattning/summary) Uppsala :  Sveriges lantbruksuniv.,  Acta Universitatis agriculturae Sueciae, 1652-6880  ; 2012:2 
ISBN 978-91-576-7686-3  
[Doctoral thesis]     
document_url: https://pub.epsilon.slu.se/8589/1/odd_v_hoglund_120210..pdf