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Novel Strategies to Target Mast Cells in Disease

Paivandy, Aida and Pejler, Gunnar (2021). Novel Strategies to Target Mast Cells in Disease. Journal of Innate Immunity. 13 , 131-147
[Article Review/Survey]

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Mast cells (MCs) are versatile effector cells of the immune system, characterized by a large content of secretory granules containing a variety of inflammatory mediators. They are implicated in the host protection toward various external insults, but are mostly well known for their detrimental impact on a variety of pathological conditions, including allergic disorders such as asthma and a range of additional disease settings. Based on this, there is currently a large demand for therapeutic regimens that can dampen the detrimental impact of MCs in these respective pathological conditions. This can be accomplished by several strategies, including targeting of individual mediators released by MCs, blockade of receptors for MC-released compounds, inhibition of MC activation, limiting mast cell growth or by inducing mast cell apoptosis. Here, we review the currently available and emerging regimens to interfere with harmful mast cell activities in asthma and other pathological settings and discuss the advantages and limitations of such strategies.

Authors/Creators:Paivandy, Aida and Pejler, Gunnar
Title:Novel Strategies to Target Mast Cells in Disease
Series Name/Journal:Journal of Innate Immunity
Year of publishing :2021
Page range:131-147
Number of Pages:17
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area
Keywords:Apoptosis, Cytotoxicity, Inflammation, Mast cells
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Additional ID:
Type of IDID
Web of Science (WoS)000619107200001
ID Code:23406
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:04 May 2021 08:23
Metadata Last Modified:04 May 2021 08:31

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