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Food contact materials: an effect-based evaluation of the presence of hazardous chemicals in paper and cardboard packaging

Selin, Erica and Svensson, Kettil and Gravenfors, Erik and Iida, Mitsura and Giovanoulis, Georgios and Oskarsson, Agneta and Lundqvist, Johan (2021). Food contact materials: an effect-based evaluation of the presence of hazardous chemicals in paper and cardboard packaging. Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment. 38 , 1594-1607
[Research article]

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Abstract

Food contact materials (FCMs) can contain hazardous chemicals that may have the potential to migrate into food and pose a health hazard for humans. Previous studies have mainly focused on plastic materials, while data on packaging materials made from paper and cardboard are limited. We used a panel of cell-based bioassays to investigate the presence and impact of bioactive chemicals on human relevant endpoints like oxidative stress, genotoxicity, inflammation, xenobiotic metabolism and endocrine system effects in extracts made from paper and cardboard. In total, 23 methanol extracts of commonly used paper and cardboard available on the Swedish market were extracted as a whole product using methanol to retrieve polar substances, and tested at concentrations 0.3-10 mg/mL and 0.2-6 mg/mL. At the highest concentration bioactivities were observed in a high proportion of the samples: oxidative stress (52%), genotoxicity (100%), xenobiotic metabolism (74%), antiandrogenic- (52%) and antioestrogenic receptor (39%). Packages of potential concern included cake/pastry boxes/mats, boxes for infant formula/skimmed milk, pizza boxes, pizza slice trays and bag of cookies. It should be noted that the extraction for packages like cake/pastry boxes can be considered exaggerated, as the exposure usually is shorter. It can be hypothesised that the observed responses may be explained by inks, coatings, contaminants and/or naturally occurring compounds within the material. To summarise, an effect-based approach enables hazard identification of chemicals within FCMs, which is a valuable tool for ensuring safe use of FCMs.

Authors/Creators:Selin, Erica and Svensson, Kettil and Gravenfors, Erik and Iida, Mitsura and Giovanoulis, Georgios and Oskarsson, Agneta and Lundqvist, Johan
Title:Food contact materials: an effect-based evaluation of the presence of hazardous chemicals in paper and cardboard packaging
Series Name/Journal:Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment
Year of publishing :2021
Volume:38
Page range:1594-1607
Number of Pages:14
Publisher:TAYLOR AND FRANCIS LTD
ISSN:1944-0049
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 205 Materials Engineering > Paper, Pulp and Fiber Technology
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Food Science
Keywords:Food packaging materials, effect-based strategy, paper and board, In vitro analysis, bioassays, hazard identification
URN:NBN:urn:nbn:se:slu:epsilon-p-112694
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112694
Additional ID:
Type of IDID
DOI10.1080/19440049.2021.1930200
Web of Science (WoS)000664388100001
ID Code:25343
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:15 Sep 2021 10:07
Metadata Last Modified:15 Sep 2021 10:11

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